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Web streams use a locking model to prevent multiple consumers from interleaving reads. When you call getReader(), the stream becomes locked. While locked, nothing else can read from the stream directly, pipe it, or even cancel it — only the code that is actually holding the reader can.
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Asher D’Addamio
For running trusted code that you wrote and reviewed, Docker with a seccomp profile is probably fine. The isolation is against accidental interference, not adversarial escape.